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Human homeostasis (homeostasis is from Greek: ὅμοιος homoios, "similar" and στάσις stasis, "standing still") is the property of homeostasis within the human body.

The human body manages a multitude of highly complex interactions to maintain balance or return systems to functioning within a normal range. These interactions within the body facilitate compensatory changes supportive of physical and psychological functioning. This process is essential to the survival of the person and to our species. The liver, the kidneys, and the brain (hypothalamus, the autonomic nervous system and the endocrine system help maintain homeostasis. The liver is responsible for metabolizing toxic substances and maintaining carbohydrate metabolism. The kidneys are responsible for regulating blood water levels, re-absorption of substances into the blood, maintenance of salt and iron levels in the blood, regulation of blood pH, and excretion of urea and other wastes.

An inability to maintain homeostasis may lead to death or a disease, a condition known as homeostatic imbalance. For instance, heart failure may occur when negative feedback mechanisms become overwhelmed and destructive positive feedback mechanisms take over. Other diseases which result from a homeostatic imbalance include diabetes, dehydration, hypoglycemia, hyperglycemia, gout and any disease caused by the presence of a toxin in the bloodstream. Medical intervention can help restore homeostasis and possibly prevent permanent damage to the organs.