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A protein synthesis inhibitor is a substance that stops or slows the growth or proliferation of cells by disrupting the processes that lead directly to the generation of new proteins.

interpretation of this definition could be used to describe nearly any antibiotic, in practice, it usually refers to substances that act at the ribosome level (either the ribosome itself or the translation factor),[2] taking advantages of the major differences between prokaryotic and eukaryotic ribosome structures.

Toxins such as ricin also function via protein synthesis inhibition. Ricin acts at the eukaryotic 60S.

Examples:

Neomycin

Geneticin, also called G418