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The only textbook written for undergraduates by teachers of the course, this bestseller presents the most current concepts in an experimental context, conveying the excitement of scientific discovery, and highlighting important advances while providing unsurpassed pedagogical support for the first-time learner. The new edition is thoroughly updated, including most notably a new chapter on innate immunity, a capstone chapter on immune responses in time and space, and many new focus boxes drawing attention to exciting clinical, evolutionary, or experimental connections that help bring the material to life.

Table of Contents

Part I Introduction
1. Overview of the Immune System
2. Cells, Organs, and Microenvironments of the Immune System
3. Receptors and Signaling: B and T Receptors
4. Receptors and Signaling: Cytokine and Chemokine

Part II Innate Immunity
5. Innate Immunity
6. The Complement System

Part III Adaptive Immunity: Antigen receptors and MHC 
7. Organization and Expression of Lymphocyte Receptor Genes
8. The Major Histocompatibility Complex and Antigen Presentation

Part IV Adaptive Immunity: Development
9. T-Cell Development
10. B-Cell Development

Part V Adaptive Immunity: Effector Responses
11. T-cell Activation, Differentiation, and Memory
12. B-cell Activation, Differentiation, and Memory
13. Effector Responses: Cell and Antibody-Mediated Immunity
14. Immune Responses in Time and Space

Part VI The Immune System in Health and Disease
15. Inflammation: Allergy and Hypersensitivities
16. Tolerance, Autoimmunity, and Transplantation
17. Infectious Diseases and Vaccines
18. Immunodeficiency Disorders
19. Cancer and the Immune System

Part VII Experimental Methods
20. Experimental Methods